Humble usually is, so just to clarify the question: You're asking if Steam will be necessary, aren't you?
Nowadays, it is not uncommon to find games on the Humble Store with third-party software requirements (origin, uplay, steam). And I know that steam is not a drm per se, steamworkshop is. And I know that some games within steam are DRM free. But you get it, my question is: will steam (or other third-party software) be necessary?
I know it has a steam page, I'm not sure if they have other platforms they are launching it on though.
If you buy it from the humble store you should get a stand alone copy and a steam key for a steam copy. That's how it usually works anyway.
I'm not exactly sure what DRM (sorry for my ignorance). I really dislike steam because of the way you have to connect to there service or whatever that is. I like GOG.com better because you can just download and install. no sign in, not online, etc. So to buy through Humble (never purchased on that site before), are you saying it would be more like buying through GOG?
In short, yes. If a humble bundle game is sold DRM free you download the installer and then you can install it anywhere without needing an internet connection.
But wait before buying it. On the Humble Store, it it NOT identified as DRM FREE. It may be a mistake; it has already happened at least once (the other way round: a steam-only game identified as drm free). I would suggest you to wait for clarification. I will EDIT: it has been corrected and is now identified as DRM FREE.