I think that would be too overwhelming...it is like once you discover the planet, you die, you respawn and then never go back there...I think something that makes you want to go back will be more enticing. I guess if you make it like a virus, than the planet must hold something really rare and awesome. They can do something like in Doctor Who, Planet of the Dead, where the alien swarm circles the planet and if you get in the way you are crushed or destroyed...in Doctor Who's case, it was getting eaten.
I love the idea of nukes and radiation/fallout that changes the landscape, mutates living things and turns water into acid or something of the sort.
Fallout does not expand to encroach an area larger than the original one, if it did, Chernobyl would have already swallowed Ukraine and Russia whole. I can deal with corruption as long as it does not planet hop, I hated how I had to barricade my Terraria world because it got two freaking strains of cancer. :S If it could expand starwards, it would be kind of a timer for hard mode, and I furiously hate timers.