You bring over 200 med kits, jump around constantly, and use your most powerful shotgun. Well at least that's how I did it XD
Well I had 200 med kits until I dropped them all on the ground accidentally and quit the game so they all disappeared... XD
Ah yes, killing that spider. The best bet is to, as with all bosses, bring lots of healing items. Bring a spear for waveclear, a blade or energy whirl one if you can find it. Guns for taking shots at the spider off screen when you can.
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