I'd recommend always going for the worst or near-worst difficulty on hardcore playthrough rules, but I gotta add, in the X-COM series I was adviced against doing so by... about 10 times more people than the rest.
Yeah...I made very little progress on anything above regular in enemy unknown..but I'm more in for the grade for effort!
Good luck in both cases, sadly, "luck" is a very much needed thing in tackling x-com on high difficulties and/or personal rules :/
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